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Literature summary extracted from

  • Basler, M.; Groettrup, M.
    No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes (2007), Eur. J. Immunol., 37, 896-904.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.11.4 expressed in HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.11.4 Ala-Ala-Phe-chloromethylketone 80% inhibition at 0.04 mM Homo sapiens
3.4.11.4 butabindide 85% inhibition at 0.1 mM Homo sapiens
3.4.14.10 Ala-Ala-Phe-chloromethyl ketone 0.03 mM Homo sapiens
3.4.14.10 butabindide 0.1 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.11.4 cytosol
-
 Homo sapiens 5829
-
3.4.14.10 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.11.4 Homo sapiens
-
-
-
3.4.14.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.11.4 BMC-2 cell
-
 Homo sapiens
-
3.4.14.10 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.11.4 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens ?
-
 ?
3.4.14.10 Ala-Ala-Phe-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens Ala-Ala-Phe + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.11.4 TPPII
-
 Homo sapiens
3.4.11.4 tripeptidyl peptidase II
-
 Homo sapiens
3.4.14.10 TPPII
-
 Homo sapiens
3.4.14.10 tripeptidyl peptidase II
-
 Homo sapiens